Biography

After receiving his B.S. from Tianjin University, Huaimin obtained his PhD. in 2015 from Nankai University under the supervision of Professor Zhimou Yang. Before starting his independent research (2019/09), he was a postdoctoral fellow with Prof. Bing Xu at Brandeis University. His research interests mainly focus on applying supramolecular assemblies of small molecules to explore and engineer living organisms; designing functional supramolecular nanomaterial for applications in materials chemistry and biomedicine.

Research

1.  Self-assembly in cell milieu
2.  Exploration of bioactive materials (e.g., molecular hydrogel) based on amino acid derivatives, peptides, and therapeutic agents in biomedicine and tissue engineering
3.  The applications of molecular hydrogel in preventing protein degradation and delivering biomacromolecules (e.g., protein and gene)
4.  Novel strategy for constructing molecular hydrogel
5.  Novel active probe for visualizing cellular activity
6.  Self-assembly of glycopeptides for detecting bacteria
7.  Intracellular self-assembly to control cell behaviors

Representative Publications

[1] Yang, X.;  Lu, H.;  Tao, Y.;  Zhang, H.; Wang, H.*, Controlling supramolecular filament chirality of hydrogel by co-assembly of enantiomeric aromatic peptides. Journal of Nanobiotechnology 2022, 20 (1), 1-12.

[2] Wu, B.;  Zhao, S.;  Yang, X.;  Zhou, L.;  Ma, Y.;  Zhang, H.;  Li, W.; Wang, H.*, Biomimetic Heterodimerization of Tetrapeptides to Generate Liquid Crystalline Hydrogel in A Two-Component System. ACS nano 2022, 16 (3), 4126-4138.

[3] Fang, Y.; Wang, H.*, Molecular Engineering of Peptide–Drug Conjugates for Therapeutics. Pharmaceutics 2022, 14 (1), 212.

[4] Wang, J., Hu, L., Zhang, H., Fang, Y., Wang, T., and Wang, H.* Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer, Adv. Mater. 2022, 34 (1), 2104704. (Selected as frontispiece)

[5]  Yang, X., Lu, H., Tao, Y., Zhou, L., and Wang, H.* Spatiotemporal Control over Chemical Assembly in Living Cells by Integration of Acid Catalyzed Hydrolysis and Enzymatic Reaction, Angew. Chem. Int. Ed. Engl. 2021, 60 (44), 23797-23804. (hot paper)

[6]  Hu, L., Li, Y.,  Lin. X.,  Huo, X., Zhang, H., and Wang, H* Structure-Based Programming of Supramolecular Assemblies in Living Cells for Selective Cancer Cell Inhibition, Angew. Chem. Int. Ed. Engl., 2021, 60 (40), 21807-21816. (Selected as frontispiece and hot paper)

[7]  Li, J.;  Fang, Y.;  Zhang, Y.;  Wang, H.;  Yang, Z.; Ding, D.*, Supramolecular Self‐Assembly‐Facilitated Aggregation of Tumor‐Specific Transmembrane Receptors for Signaling Activation and Converting Immunologically Cold to Hot Tumors. Adv. Mater. 2021, 33 (16), 2008518.

[8] Yang, X., Cao, Z., Lu, H., and Wang, H.* In Situ Construction of Functional Assemblies in Living Cells for Cancer Therapy,  Adv. Healthcare Mater.., (2021): 2100381.

[9] Wang, H.^#, Feng, Z.^#, Xu, B.^*, Intercellular Instructed-Assembly Mimics Protein Dynamics to Induce Cell Spheroids, J. Am. Chem. Soc., (2019). (# co-first authors)

[10] Wang, H., Feng, Z., Del Signore, S. J., Rodal, A. A., Xu, B.^*, Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Time Scales and Areas, J. Am. Chem. Soc., 140 (2018) 3503-3509.

[11] Wang, H., Shi, J., Feng, Z., Zhou, R., Wang, S., Rodal, A. A., Xu, B.^*, An in Situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3d Cell Spheroids, Angew. Chem. Int. Ed. Engl., 56 (2017) 16297-16301. (VIP paper)

[12] Wang, H., Feng, Z., Xu, B.^*, Bioinspired Assembly of Small Molecules in Cell Milieu, Chem. Soc. Rev., 46 (2017) 2421-2436.

[13] Wang, H, Feng, Z., Lu, A., Jiang, Y., Wu, H., Xu, B.^*, Instant Hydrogelation Inspired by Inflammasomes, Angew. Chem. Int. Ed. Engl., 56 (2017) 7579-7583.

[14] Wang, H., Feng, Z., Wu, D., Fritzsching, K. J., Rigney, M., Zhou, J., Jiang, Y., Schmidt-Rohr, K., Xu, B.^*, Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells, J. Am. Chem. Soc., 138 (2016) 10758-10761.

[15] Wang, H., Feng, Z., Wang, Y., Zhou, R., Yang, Z., Xu, B.^*, Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance, J. Am. Chem. Soc., 138 (2016) 16046-16055.